Ozone application on skin infections

Ozone antiseptic

Antibacterial effect of topical ozone on the treatment of MRSA skin infection 

Keywords: Ozone application of skin infections,


“Skin can be infected by many types of microorganisms, most commonly by gram‑positive strains of Staphylococcus and Streptococcus spp. Treatment of Staphylococcus aureus (S. aureus) infections, particularly that of methicillin resistant Staphylococcus aureus (MRSA), is a challenge in clinical practice.”

“Ozone therapy has proven to be one of the strongest antiseptics against the majority of microorganisms involved in skin infections.” (1)

Ozone antiseptic qualities

Clinical Study

“The purpose of the present study was to evaluate the microbicidal effects of topical ozone therapy on S. aureus and MRSA, and determine the clinical efficacy of ozone therapy on patients with MRSA skin infection.” (1)

“Skin and soft tissue bacterial infections occur frequently in the general population. They are characterized by erythema, edema, and/or inflammation (1). and usually begin with an inflammatory process in epidermis, dermis, or subcutaneous tissues, they can spread to other parts of the body, leading to more serious symptoms.

Antibiotic therapy is the option of choice for the treatment. However, most of antibiotics could lose their potency over time due to a development of antimicrobial resistance. Microbial resistance to Staphylococcus aureus (S. aureus), especially methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant-MRSA, is a grand challenge in clinical practices globally.

Ozone is naturally occurring gaseous molecule of triatomic allotrope of oxygen, formed recombination of oxygen atoms and represented as O3. The original application of Ozone was to sterilize microorganisms in drinking water. Now ozone has been used for treatment of open wounds, Herpes Zoster and Herpes Simplex (2), because of its anti-microorganism effectiveness. Additionally, ozone has other advantages like such as improving wound healing, enhancing immune, no side effect, no-toxic, environmental friendly and high efficacy.” (1) (Ozone application of skin infections).

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