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Ozone Therapy in Internal Diseases

Ministry of Health Service of The Russian Federation

The State Medical Academy of  Nizhny Novgorod

Keywords: Atherosclerosis, Ischemic Heart Disease, Hypertensive Disease, Diabetes Mellitus, Chronic Bronchitis, Chronic Pyelonephritis, Chronic Gastritis, Ulcer, Chronic Nonulcerative Colitis, Chronic Hepatitis, Ozone Therapy

Atherosclerosis and Ischemic Heart Disease 

Ozone has been found to produce hypolipidemic effect. According to different authors
(Камышева Е.П. с соавт., 1998, Густов А.В. с соавт., 1999, Быков с соавт., 2000), after
the course of ozone therapy patients with atherosclerosis had evident decrease in the levels of
total cholesterin (6,4-18,4%), of lipoproteins of low density(7 – 28,7%), of triglycerides (10,5
– 17,2%) and increase of lipoproteins of high density(3,7 – 6,8%) levels.

“Ozone therapy proved to be effective in all IHD patients (stenocardia, cardiosclerosis,
arrhythmias) at various stages of the disease from mild forms to severe ones). Its efficiency
was found to be more pronounced in severe forms for it helps to control hypoxia in tissues
which develops with the advance of heart insufficiency. In tissues with insufficient blood
circulation the oxygen uptake by cells is done in much greater volume under ozone influence,
This effect cannot be achieved with the help of medication orders. This statement seems to be
extremely important for it explains the positive effect of the method.”(1)

Routes

  • Intravenous infusions with 200ml of ozonated saline with ozone concentration of
    20µg/kg of patient’s weight (ozone concentration at the output from the generator)
  • Rectal insufflations with ozone/oxygen mixture, ozone dose being 75µg/kg of
    patient’s weight
  • Major Autohemotherapy, ozone dose being 1-3 mg.

Management 

In the course of treatment we use one of these routes The management is done according to
the patient’s condition, which is evaluated on the basis of the accepted functional classes
(FC):

  • 6-8 procedures for FC-I patients;
  • 8-10 procedures for FC-II patients;
  • 8-10 procedures for FC-III and FC-IV patients.

The first 2 procedures of intravenous infusions or rectal insufflations are to be done every
day, the rest – every second day. The procedures (6-8) of major autohemotherapy are to be
done twice a week.

Note. In cases when patients are on conventional treatment and start ozone therapy,
coronaroactive preparations are not discontinued immediately. The dose is gradually
diminished with the improvement of patient’s condition.
The following table presents the results we received on having used ozone therapy for 142
patients with different FC of IHD.

 

 

The improvement in the condition of patients with stenocardia was defined by the less
episodes of heart strokes and nitroglycerinum intake. Angina attacks were completely
regulated in 50% of patients; in 41% of patients the number of attacks was double decreased.

 

Hypertensive Disease 

“Ozone therapy is a pathogenic method for hypertension treatment. It corrects the decreased
energy of cells, the main component of pathogenesis. No other available hypotensive
preparations are known to have such properties. In the management of Hypertensive disease
ozone therapy can be used as a monotherapy and in combination with other medications. As a
monotherapy it is efficient in patients at the initial stage of the disease, in mild, labile
hypertension. Positive results were received in 70% of patients.”

“Patients with steady hypertension are to combine ozone therapy with hypotensive
preparations. According to our findings, conventional hypotensive preparations can be
administered in lower doses when combined with ozone therapy. In combined treatment
clinical manifestations of hypertensive disease, such as headaches, dizziness, heart pains –
either disappeared within a shorter time period or abated.”(1)

Routes 

  • Intravenous infusions with 200ml of ozonated saline with ozone concentration of
    20µg/kg of patient’s weight (ozone concentration at the output from the generator)
  • Rectal insufflations with ozone/oxygen mixture, ozone dose being 75µg/kg of
    patient’s weight
  • Major Autohemotherapy, ozone dose being 1-3 mg.

Management 

“In the course of treatment we use one of these routes. The treatment with intravenous
infusions or rectal insufflations starts with 2-3 daily procedures, the rest 3-4 procedures are
done every second day. With the decrease of arterial pressure the number of procedures is
diminished to two procedures a week, and then one procedure a week. The total number of
procedures is 8-10. Major autohemotherapy is done twice week with a total number of
procedures up to 6-8.”(1)

Diabetes Mellitus

Ozone therapy appears to be an effective method for DM treatment. The reason is in ozone
mechanisms when it can perform a number of processes, which provide its positive effect.

First, ozone improves the penetration of cellular membranes for glucose. It is achieved by
stimulating pentose-phosphate pathway and aerobic glycolisis that in case of DM are
inhibited. It promotes hyperglycemia decrease due to better transport of glucose into tissues.
We observed a group of 70 patients with insulin-dependent and non-insulin-dependent
diabetes. After the course of ozone therapy the average level of hyperglycemia had a 26%
decrease.

Ozone activates glucose metabolism that results in increasing content of 2,3
diphosphoglycerate in erythrocytes which provides better oxygen supply into the tissues.
Patients with diabetes mellitus have the so called glycosylated hemoglobin forming very
strong bonds with oxygen, thus, inducing hypoxia and determining the severity of the
disease. That is why hypoxia control with the help of ozone therapy is of the key importance
in the course of treatment.

After the course of ozone therapy the patients had significant decrease in the levels of urine,
cholesterol and fibrinogen.

Routes

  • Intravenous infusions with ozonated saline
  • Rectal insufflations with ozone/oxygen mixture
  •  Major Autohemotherapy
  • Minor Autohemotherapy
  • Subcutaneous microinjections with ozone/oxygen mixture
  • Stimulation of biological active points with ozone/oxygen injections

Management 

“The basic treatment includes intravenous infusions of ozonated saline or rectal insufflations
with ozone/oxygen mixtures which are done every second day (8-10 procedures). These
procedures can be substituted with major autohemotherapy which is done twice a day up to 6-
8 procedures for the course of treatment. Other procedures are administered according to the
type of diabetes mellitus and the presence of complications.”

“In DM, Type-2 the treatment course also includes stimulation of biological active points with
ozone/oxygen injections using the conventional schemes.
In signs of secondary immune deficiency (pustular inflammatory diseases) in addition to the
basic course of treatment subcutaneous microinjections with ozone/oxygen mixture are done
in the area of purulent foci. Minor autohemotherapy is done every second day up to 6-8
procedures for the course.”

Note. Due to the fact that ozone has hypoglycemic effect the dose of glucose decreasing
preparations must be corrected and glucose level in the blood must be under constant control
through out the course of treatment.

“Positive effect was received in 92% of insulin-dependent cases and 89% of non-insulindependent cases.”

Chronic Bronchitis. Bronchial Asthma 

“Ozone immune modulating properties are of primary importance in the treatment of chronic
bronchitis. Ozone therapy provides anti-infection immune response to viral-bacterial infection
invading the human body. It is revealed in intensifying local and general immunity which is
suppressed in chronic bronchitis.”

“The principles in the treatment of bronchial asthma are known to be the following: activation
of immune system and elimination of the following factors – viral and bacterial infection,
bronchoconstriction, allergic reactions, hypoxia.”(1)

Routes

  • Intravenous infusions with ozonated saline
  • Rectal insufflations with ozone/oxygen mixture
  • Major Autohemotherapy
  • Stimulation of biological active points with ozone/oxygen injections
  • Inhalations with ozonated distilled water

Management 

The treatment is a complex one, including all the above enumerated routes. The course starts
with 2 intravenous infusions of ozonated saline or rectal insufflations done daily. On
improving the condition the next 5-7 procedures are done every second day and then once or
twice a week (up to 7-10 procedures for the whole course)
Acupuncture with ozone/oxygen mixture is done according to conventional accepted
methods.

Inhalations with ozonated distilled water are done once or twice a day daily for a period of
10-15 days.

Major autohemotherapy is administered in cases when positive effect is not received after
7-10 days of treatment and it is done instead of intravenous infusions or rectal
insufflations. Procedures are done every second day up to 4-8 for the course of treatment.
The results of ozone therapy in chronic bronchitis in our practice are the following: the
condition improved in 79% of patients, 29% having significant improvement( complete
elimination of such symptoms as cough, breathlessness, weakness, rales) and 21% having
satisfactory improvement.

Ozone therapy in 42 patients with bronchial asthma followed in our clinic gave the following
results. The majority of patients (83%) had a moderate course of the disease. All the patients
were on broncholytic preparations, some of them taking steroid hormones. After the course of
ozone therapy the valid improvement in the condition was noted in 86% of patients who had
half fewer episodes of suffocation and could reduce he dose of conventional preparations. In
7% of patients we achieved a complete control of asthmatic attacks and discontinue the intake
of medications. In the rest 7% of cases we could not achieve improvement in their condition.

 

Chronic Pyelonephritis 

Routes

  • Intravenous infusions with ozonated saline
  • Rectal insufflations with ozone/oxygen mixture
  • Major Autohemotherapy
  • Minor Autohemotherapy

Management 

“The treatment combines minor autohemotherapy (6-8 injections) with intravenous infusions
of ozonated saline or with rectal insufflations with ozone/oxygen mixture (8 – 10 procedures).
During the first three days the procedures are to be done daily and then every second day.
Major autohemotherapy (6-8 procedures) is to be done twice a week and can be used as an
alternate method, substituting the first three.”(1)

Chronic Gastritis. Type ‘B’ 

“Ozone therapy proved to be an effective remedy in the treatment of chronic gastritis. Its anti-inflammatory effect is achieved due to oxidation of arachidonic acid, known as a precursor for prostaglandin E that starts the inflammatory process. To add to that, ozone produces its immune-modulating, anti-aggregation and analgetic effect”(Андосов С.В. с соавт., 2000).

“Ozonated oil and ozonated water produce bactericidal effect and deliver active oxygen to
tissue, shortening the healing processes.”(1)

“Ozone has been found to produce changes in the local immunity, increasing the release of
secretory IgA by lymphocytes and plasmatic cells, responsible for the immune defense of the
surface cells of the stomach.”(1)

Routes

  • Ozonated water
  • Ozonated oil
  • Minor Autohemotherapy
  • Stimulation of biological active points with ozone/oxygen injections

Management 

“The treatment consists of daily intake of ozonated water (100-150ml) 30-40 minutes before
meals 1-3 times a day. Ozonated oil is to be taken 3 times a day 15 minutes following the
intake of ozonated water, starting with 1 teaspoonful, gradually increasing the dose to
tablespoonful, if patients tolerate it well. The water and oil are to be taken for 2 – 3 weeks.
Minor autohemotherapy is to be done according to the following scheme.”(1)

“The first 3 procedures are to be done daily, the next 3 – every second day, and the remaining procedures
– twice a week. The course consists of 8-10 procedures. Acupuncture with ozone/oxygen mixture are done according to the conventional methods.”(1)

Ulcer (Stomach, Duodenum)

Multifunctional ozone effect in the treatment of peptic ulcer is revealed first of all in its antiinflammatory and anti-helicobacterial action.

V.Maximov (1998) considering different schemes of ulcer treatment
comes to the conclusion, that ozone therapy can substitute antibiotics and metronidasol
preparations, providing better results regarding the ulcer healing and the degree of HP
eradication.

“Ozone therapy was found to produce positive effect on general and local immunity.”

Routes (Stomach)

  • Ozonated water
  • Ozonated oil
  • Rectal insufflations with ozone/oxygen mixture
  • Minor Autohemotherapy
  • Intravenous infusions with ozonated saline
  • Major Autohemotherapy
  •  Stimulation of biological active points with ozone/oxygen injections

Management

“Ozonated water and ozonated oil are to be taken following the scheme of the chronic gastritis.
The treatment begins with rectal insufflations with ozone/oxygen mixture done every second
day up to 5-6 procedures.”

“Starting from the second week the treatment is complemented with
Minor autohemotherapy alternately with rectal insufflations. During the 3-d and the 4-th
weeks the same procedures are done every second or third day.”

“In cases when rectal insufflations are unacceptable, they are substituted by intravenous infusions with ozonated saline up to 12-15 procedures done every second day or by major autohemotherapy done
twice a week with 6-8 procedures for the course.”(1)

Routes (Duodenum)

  • Ozonated water
  • Ozonated oil
  • Minor Autohemotherapy
  • Major Autohemotherapy
  • Intravenous infusions with ozonated saline
  • Rectal insufflations with ozone/oxygen mixture
  • Stimulation of biological active points with ozone/oxygen injections

Management

Ozonated water and ozonated oil are to be taken following the scheme of the chronic gastritis.
The course begins with minor autohemotherapy procedures. The first 3 procedures are to be
done daily, then 2 or 3 procedures are to be done every second day, the remaining ones are to
be done twice a week. The course includes 8-10 procedures.

Starting with the second week the treatment is complemented with intravenous infusions with
ozonated saline or rectal insufflations with ozone/oxygen mixture up to 3-4 procedures that
are alternated with minor Autohemotherapy.

Intravenous infusions of ozonated saline and minor autohemotherapy can be substituted by
major autohemotherapy (8-10 procedures), the first two procedures are to be done every
second day and afterwards – twice a week.

Ozone acupuncture is done according to the conventional methods.
The treatment course lasts 3-4 weeks. After cicatrization, ozonated oil is kept on to be taken
1 spoonful before going to bed at night for a period of 1-1,5 month.

“In our practice we used ozone therapy as a mono therapy in 69 patients at the stage of
exacerbation, 10 suffering from ulcer of the stomach, 59 from duodenal ulcer.
The results of treatment were regarded as “significant improvement” in 8 patients with
complete healing of the ulcerative defect and disappearance of all the symptoms. In 2 cases
the results were assessed as “improvement of the condition”, for the healing was not
complete, though the symptoms disappeared completely. “(1)

Note. Ozone therapy can be used both as a mono therapy and in combination with medicinal
forms.

Chronic Nonulcerative Colitis 

“Ozone therapy in the management of patients with chronic non-ulcerative colitis takes a
special place regarding the following reasons.”

“First, the use of rectal insufflations with ozone /oxygen mixture produces both topical antiinflammatory effect and general multi-faceted including anti-hypoxic, immune-modulating,
etc due to ozone capacity to be quickly absorbed by blood.”

“Second, chronic colitis is often concomitant with dysbacteriosis. Ozone advantages become
evident, for if does not produce any harmful effect on flora of the intestine, compared with
antibacterial preparations such as antibiotics and sulfanilamides.”

“When rectal insufflations are used ozone gets stuck to mucous membrane and interferes with
the infectious process penetrating the microbial cells thus preventing their further
reproduction Besides, ozone enforces phagocytosis, improving blood circulation and humoral
immunity. It leads to refection of homeostasis, with the normalization of microbial balance
and subsiding inflammatory signs.”

“Contrary to various antiseptics still causing some damaging effect in tissues, ozone does not
produce any harmful or ulcerative effect and, more than that, it does not induce any resistance
to ozone therapy”(1)

Routes

  • Rectal insufflations with ozone/oxygen mixture
  • Minor Autohemotherapy
  • Stimulation of biological active points in the lower extremities with ozone/oxygen
    injections

Management 

“During the exacerbation period ozone insufflations of gaseous mixture are done every second
day with the dose of 100µg per kg of patient’s weight for the first two weeks, then 2 times a
week with the dose of 75µg/kg. The whole course consists of 10-15 procedures.
Minor autohemotherapy is done 1-2 times a week up to 4-6 injections for the course.”

“Microinjections with ozone/oxygen mixture into the paravertebral points at Th 10 – L5 level
are to be done daily or every second day up to 5-7 procedures for the course. Acupuncture
procedures with ozone/oxygen mixture are done according to the conventional methods.
In colitis of various etiology some authors (В.А.Максимов с совт. -1998) recommend the use
of intra-intestinal gaseous ozone up to 200-500ml with the concentration 60 mg/l.”

“In the Russian Centre of Restorative Medicine and Spa-resort Treatment they recommend
rectal insufflations with concentration in the range of 10-40µg/ml and volume of 50-300ml
for patients with inflammatory intestinal diseases. In atonic intestine they recommend low
concentrations, in spastic conditions – higher concentrations.”(1)

Chronic Hepatitis 

“In the treatment of infectious hepatitis the major effect is achieved due to ozone antiviral
property. Inactivation of viruses results from peroxide oxidative activity when virus cell
receptors get destroyed and cannot penetrate the host cell. The failure in virus multiplication
process is also caused by RNA virus breakdown due to ozone. According to A.Zmyzgova
(А.В.Змызговой с соавт.-1998) 2-months ozone therapy courses reveals no viraemia signs
in 66% of cases with chronic viral B-hepatitis, and in 60% of cases with chronic C-hepatitis.”(1)

Routes 

  • Rectal insufflations with ozone/oxygen mixture
  • Minor Autohemotherapy
  • Intravenous infusions with ozonated saline
  •  Major Autohemotherapy

Management 

“Apart from the exacerbation period the most common procedures in chronic hepatitis are
rectal insufflations with the dose of ozone of 75µg/kg done alternately with minor
autohemotherapy. For the first two weeks rectal insufflations are done every second day and
then twice a week up to 20-30 procedures for the course. Minor autohemotherapy is done 2
times a week.”

“The preference for rectal insufflations can be explained by findings published by H.G.Knoch
(1987,1988). Ozone/oxygen mixture infused via the rectum is of particular significance in the
treatment of different forms of hepatitis.”(1)

“Hepatic cells affected by the virus are less resistant to peroxide action compared with healthy
cells. These weakened cells on being exposed to high peroxide concentration get destroyed
alongside with viruses and eliminated. This phenomenon is described by A. Bolcany (1989),
who revealed the elevation of transaminase level after the very first procedures of ozone
therapy and explained it by the destruction of hepatic cells due to viral invasion.”(1)

Ozone injection

Source 

  • (1) http://www.absoluteozone.com/assets/ozone_therapy_in_practice.pdf– Oleg V. Maslennikov, Claudia N. Kontorshchikova, Irina A. Gribkova- Nizhny Novgorod, Russia, 2008
  • Ozone therapy in Practice. Health Manual. – Nizhny Novgorod
  • Rilling S.,Viebahn R. The Use of Ozone in Medicine. New Jork. Haug. 1987.
  • Bocci V. Autohaemotherapy after treatment of blood with ozone. // Areapprais. 1.-
    Int.-Med.-Res.-1994.5-6.-№22(3).-p.131-144.

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