Study 1

Xenon therapy during therapeutic hypothermia in neonatal encephalopathy: a feasibility study

Material and methods:

The study was conducted to evaluate the effective utility of single breath xenon in diagnosing pulmonary embolism by comparing them with pulmonary perfusion scans in patients with obstructive diseases. 33 subjects were studied with obstructive disease and abnormal perfusion scan. Their perfusion scan and single breath tests were compared and assessed for determination of pulmonary embolism.


Out of 33 subjects, 25 patients had abnormalities matching on both scans but only one (4%) had a pulmonary embolism. Other eight patients had no matching perfusion and single breath tests but four (50%) of them had pulmonary embolia.


Patients with obstructive pulmonary disease, having the indeterminate possibility of pulmonary emboli should be further classified by using single breath test using xenon gas.