Study 2

Perfusion and ventilation scans in patients with extensive obstructive airway disease: Utility of single-breath Xenon

Material and methods:

In 14 cooled neonates with encephalopathy, xenon therapy was given. 1 subject was given 25% xenon and 13 were exposed to 50%. They were followed up for 18 months after exposure and studied for side effects and brain activity.

Results:

No respiratory, cardiovascular or extubation side effects were present. Xenon suppressed seizure and boosted sedation. Out of 14 subjects, three died and 7 survivors showed significant physical and mental development at follow-up.

Conclusion:

Exposing neonates with encephalopathy, to 50% xenon is feasible after 18 to 72 hours cooling. During follow-up for eighteen months, there were no side effects visible in the brain or physical development.