Study 6

Ozone Therapy as add-on treatment in fibromyalgia management by rectal insufflation: an open-label pilot study

Material and methods:

This research was conducted at the University of Granada, Spain. The purpose of this study was to determine the effective of ozone therapy as an add-on in the treatment of fibromyalgia.

The study participants comprised of fibromyalgia sufferers who were given ozone therapy for a period of 12 weeks. At the end of each session, Fibromyalgia Impact Questionnaire (FIQ) was given to the patients to fill.


At the end of each session and at different concentrations of ozone used, patients reported a significant reduction in pain.


Ozone is an effective adjuvant therapy that can be used in the management of pain disorders like fibromyalgia.